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channel blocker : ウィキペディア英語版
channel blocker
A channel blocker (CB) or ion channel blocker (ICB) is a type of drug which binds inside the pore of a specific type of ion channel and blocks the flow of ions through it, resulting in an alteration of the electrochemical gradient of the cell membrane of neurons and therefore a change in neurotransmission.
==Types of Channel Blockers==
There are several different major classes of channel blockers, including:
* Calcium (Ca2+) channel blockers
* Chloride (Cl) channel blockers
* Potassium (K+) channel blockers
* Sodium (Na+) channel blockers
The following types which act on ligand-gated ion channels (LGICs) via binding to their pore also exist:
* 5-HT3 receptor antagonists
* AMPA receptor antagonists
* GABAA receptor antagonists
* Glycine receptor antagonists
* Kainate receptor antagonists
* nACh receptor antagonists
* NMDA receptor antagonists
* P2X receptor antagonists
* Zinc (Zn2+)-activated channel antagonists
These types of receptor antagonists are referred to as noncompetitive or uncompetitive.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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